Close Relative of Human Middle East Respiratory Syndrome Coronavirus in Bat, South Africa
نویسندگان
چکیده
Abdolrazagh Hashemi-Shahraki, Parvin Heidarieh, Samira Azarpira, Hasan Shojaei, Mohammad Hashemzadeh and Enrico Tortoli Author affiliation: Pasteur Institute of Iran, Tehran, Iran (A. Hashemi-Shahraki, S. Azarpira, M. Hashemzadeh); Alborz University of Medical Sciences, Karaj, Iran (P. Heidarieh); Isfahan University of Medical Sciences, Isfahan, Iran (H. Shojaei); and San Raffaele Scientific Institute, Milan, Italy (E. Tortoli)
منابع مشابه
Middle East Respiratory Syndrome Coronavirus (MERS-CoV): A Review Article
The recently emerged Middle East respiratory syndrome coronavirus (MERS-CoV) emerged in the Middle East region in 2012. The virus is phylogenetically related to bat CoV, but other animal species like camels and goats may potentially act as an intermediate host by spreading the virus to humans. This virus is thought to cause a severe disease in patients with underlying comorbidities. Laboratory ...
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To understand how Middle East respiratory syndrome coronavirus (MERS-CoV) transmitted from bats to humans, we compared the virus surface spikes of MERS-CoV and a related bat coronavirus, HKU4. Although HKU4 spike cannot mediate viral entry into human cells, two mutations enabled it to do so by allowing it to be activated by human proteases. These mutations are present in MERS-CoV spike, explain...
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